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Anti-protozoal Effect of Steroid Hormone 20-hydroxyecdysone

NCT04827537 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2025-04-04

No results posted yet for this study

Summary

20-hydroxyecdysone is an ecdysteroid hormone found in invertebrates and plants. 20-hydroxyecdysone exhibits a broad range of biological properties in various in vitro and in vivo models, including anabolic, antioxidant, anti-inflammatory, immunomodulatory, anti-obesity and antidiabetic activities, in addition to acting as neuroprotective and hepatoprotective agent. Ecdysteroids are widely used by athletes as dietary supplements to increase strength and muscle mass during resistance training, to reduce fatigue and to ease recovery. Mhashilkar AS et al. (2016) were revealed anti-parasitic activity of 20-hydroxyecdysone against the human filarial parasites. According to recent searches in academic databases and medical search engines (Google, www.google.com; PubMed, www.ncbi.nlm.nih.gov/pubmed; and Medline, www.medline.com), no studies have been conducted to assess the anti-protozoal activity of 20-hydroxyecdysone.

The aim of the study is to assess anti-protozoal activity of 20-hydroxyecdysone in water sports athletes with giardiasis.

Conditions

  • Giardia Lamblia Infection

Interventions

DRUG

20-hydroxyecdysone Oral

100 mg (one pill) x two times a day orally, 10 consecutive days

DRUG

Metronidazole Oral

500 mg (one pill) x two times a day orally, 10 consecutive days

DRUG

Placebo Oral

100 mg (one pill) x two times a day orally, 10 consecutive days

Sponsors & Collaborators

  • Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan

    lead OTHER_GOV

Principal Investigators

  • Abdurakhim Toychiev, PhD · research institute of epidemiology, microbiology and infectious diseases

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
27 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2026-12-31
Completion
2027-12-31

Countries

  • Uzbekistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04827537 on ClinicalTrials.gov