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Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults

NCT03373214 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2021-01-13

No results posted yet for this study

Summary

Na-GST-1 is a protein expressed during the adult stage of the Necator americanus hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source. Vaccination with recombinant Na-GST-1 has protected dogs and hamsters from infection in challenge studies. This study will evaluate the safety and immunogenicity of administering Na-GST-1 with or without the CpG 10104 immunostimulant to healthy Gabonese adults living in an area of endemic hookworm infection.

Conditions

  • Hookworm Infection
  • Hookworm Disease

Interventions

BIOLOGICAL

Na-GST-1

Na-GST-1/Alhydrogel®

BIOLOGICAL

CPG 10104

CPG 10104

Sponsors & Collaborators

  • Centre de Recherche Médicale de Lambaréné

    collaborator OTHER

  • George Washington University

    collaborator OTHER

  • Leiden University Medical Center

    collaborator OTHER

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    collaborator OTHER

  • Amsterdam Institute for Global Health and Development

    collaborator OTHER

  • Baylor College of Medicine

    lead OTHER

Principal Investigators

  • Ayola Adegnika, MD · Centre de Recherches Medicales de Lambarené

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-01
Primary Completion
2019-02-28
Completion
2019-03-30
FDA Drug
Yes

Countries

  • Gabon

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03373214 on ClinicalTrials.gov