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CTC Quantification During TURBT and PKVBT of Transitional Cell Carcinoma in Purging Fluid and Blood

NCT04811846 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2024-12-09

No results posted yet for this study

Summary

Transurethral resection of bladder tumor (TURBT) is usually performed in a piecemeal technique. Tumor fragmentation and cell spilling could be responsible for high recurrence rates. Circulating tumor cells (CTCs) have been shown to be a prognostic predictor in disease progression in transitional cell carcinoma. In the current study the investigators aim to quantify CTCs in purging fluid and blood for recurrent intermediate risk bladder cancer during surgery for two different methods: TURBT and Plasma-kinetic vaporization of bladder tumor (PKVBT). Also correlations for recurrence will be investigated for the two different surgical methods.

Conditions

  • Urinary Bladder Neoplasm
  • Transitional Cell Carcinoma
  • Urogenital Neoplasms
  • Circulating Tumor Cell
  • Neoplasms

Interventions

DEVICE

Bipolar transurethral resection of bladder tumor (TURBT)

Standard resection in piecemeal technique with standard bipolar cutting loop. (Storz medical, 27040 GP1)

DEVICE

Bipolar transurethral plasma kinetic vaporization of bladder tumor (PKVBT)

Vaporization of bladder tumor with standard bipolar vaporization electrode. (Storz medical, 27040 NB)

Sponsors & Collaborators

  • Salzburger Landeskliniken

    collaborator OTHER

  • University Teaching Hospital Hall in Tirol

    lead OTHER

Principal Investigators

  • Udo Nagele, MD, Prof. · Head of Department LKH Hall in Tirol

  • Lukas Lusuardi, MD, Prof. · Heas of Department LKH Salzburg

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-03-14
Primary Completion
2025-05-31
Completion
2025-10-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04811846 on ClinicalTrials.gov