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Detection and Clinical Significance of Circulating Cancer Cells in Patient Undergoing Radical Cystectomy

NCT02345473 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 59

Last updated 2015-01-26

No results posted yet for this study

Summary

Very few factors may be identified as prognostic for patients with bladder cancer undergoing radical cystectomy. Recently, detection of circulating tumor cells has shown to be very promising in anticipating both the likelyhood of distant metastases and survival in patients with breast cancer, melanoma, prostate cancer and other malignancies. In the present study we both tested the detection rate of circulating tumor cells using a PCR based methodology in the peripheral blood of patients undergoing radical cystectomy, and we further correlated our results with their clinical outcome.

Conditions

Interventions

GENETIC

Detection of circulating tumor cells in blood samples

Ficoll based isolation of mononuclear cells from the peripheral blood of patients undergoing radical cystectomy, nucleic acids extraction and, finally, PCR based detection of sequences specific to cytokeratins.

Sponsors & Collaborators

  • Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari

    lead OTHER

Principal Investigators

  • Vincenzo VP Pagliarulo, Urologist · Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-01-31
Primary Completion
2014-10-31
Completion
2014-10-31

Countries

  • Italy

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02345473 on ClinicalTrials.gov