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Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer

NCT05524012 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2025-09-08

No results posted yet for this study

Summary

This pilot study aims to trial multimodal early response assessment to enable therapy adaptions in the context of non-operative therapy strategies of locally advanced rectal cancer (LARC) for development of a non-invasive response prediction model.

Conditions

  • Locally Advanced Rectal Carcinoma
  • Neoadjuvant Treatment
  • Radiotherapy
  • Adaptive Treatment

Interventions

DIAGNOSTIC_TEST

Blood sample

longitudinal blood samples for CTC monitoring

DEVICE

MRI scan

longitudinal MRI scans (non-contrast enhanced)

Sponsors & Collaborators

  • Jena University Hospital

    lead OTHER

Principal Investigators

  • Andrea Wittig-Sauerwein, MD · Department for Radiotherapy and Radiooncology, Jena University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-11-30
Primary Completion
2026-01-31
Completion
2030-09-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05524012 on ClinicalTrials.gov