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Association Between the Composition of the Intestinal Microbiota and Tumor Response in Locally Advanced Rectal Cancer

NCT06181201 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 2

Last updated 2026-03-18

No results posted yet for this study

Summary

This is an observational, single-centre study (RIPH3) for patients with rectal cancer soon to be treated with chemotherapy (+/- neo-adjuvant radio-chemotherapy) looking at the relationship between the composition of the gut microbiota before treatment and the tumour response after chemotherapy +/- radio-chemotherapy

Conditions

  • Cancer of Rectum

Interventions

PROCEDURE

Stool collection

Stool collection is done with the "Coll-off" device (Zymo research, reference R1101-2-5) provided to the patient before and after the induction treatment and after the reference chemo-radiotherapy treatment (Cap50, Capecitabine). Collection must be carried out by the patient at home (collection using the "Coll-off" device and then transfer to a coproculture jar provided). The fresh sample is then picked up the same day by an approved transporter mandated by the promoter and will be stored at -20°C until the start of the analyses

Sponsors & Collaborators

  • Institut National de la Santé Et de la Recherche Médicale, France

    collaborator OTHER_GOV

  • L'Institut des sciences moléculaires (iSm2 UMR CNRS 7313)

    collaborator UNKNOWN

  • Centre Oscar Lambret

    lead OTHER

Principal Investigators

  • Mathias CHAMAILLARD · Institut National de la Santé Et de la Recherche Médicale, France

  • Mehrdad JAFARI · Centre Oscar Lambret

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-19
Primary Completion
2024-10-08
Completion
2024-10-08

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06181201 on ClinicalTrials.gov