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Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens

NCT04792697 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-05-06

No results posted yet for this study

Summary

Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times. Many studies find that this increases the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if there are interventions that might help to modify these disruptions is unknown. Project 2 (P2) of the CARRS center will test an innovative and mechanistic model of brain circuitry that uses multi-method approaches, takes a developmental perspective, and incorporates key sleep and reward constructs.

Conditions

  • Delayed Sleep Phase Syndrome

Interventions

OTHER

Increase morning bright light

Participants will wear Re-Timer bright glasses for 30 minutes each morning upon rising

OTHER

Decrease evening blue light

Participants will wear tinted glasses that block blue wavelength light for 2 hours before bed

BEHAVIORAL

Sleep Scheduling

Participants will advance their bedtime by 1.5 hours and regularize their wake time

BEHAVIORAL

Monitor sleep, mood, and substance use

Participants will complete smartphone-based sleep, mood, and substance use monitoring

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Brant Hasler, PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
13 Years
Max Age
15 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-05-01
Primary Completion
2026-05-31
Completion
2026-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04792697 on ClinicalTrials.gov