Long-Term Outcomes of Hip Interventions for Children With Cerebral Palsy

Summary

Children with severe cerebral palsy (CP) are at high risk for progressive hip displacement, associated with pain and contractures interfering with many aspects of care, comfort and quality of life. These children undergo many types of interventions, the optimal timing and effectiveness of which, remain unclear. In 2014, CIHR funded the CP Hip Outcomes Project (CHOP), an international multi-centre prospective longitudinal cohort study of children with severe (non-ambulant) CP with evidence of hip displacement defined as a Reimer's migration percentage (MP) of at least 30%. The study was designed to evaluate the comparative effectiveness of different treatment strategies to prevent or relieve symptoms associated with hip instability, using the validated Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD ) questionnaire as the primary outcome measure of health-related quality of life © (HRQL) for this population. 650 patients enrolled from 28 sites in 11 countries, are actively being followed and will reach at least 2 years of follow-up at the end of 2019. This project, will study the impact of hip instability and its management in children with severe CP using the CPCHILD questionnaire that was developed specifically for this purpose. Although CHOP will define outcomes at 24 months, the outcomes are not expected to remain stable while the child is still growing. The inception cohort will need follow-up until skeletal maturity to track their long-term outcome trajectories.

Conditions

• Cerebral Palsy

Sponsors & Collaborators

• Royal Children's Hospital

  collaborator OTHER

• Shriners Hospitals for Children,Canada

  collaborator UNKNOWN

• Provincial Health Services Authority

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Sheba Medical Center

  collaborator OTHER_GOV

• Seoul National University Bundang Hospital

  collaborator OTHER

• Starship Children's Hospital of New Zealand

  collaborator UNKNOWN

• Poznan University of Medical Sciences

  collaborator OTHER

• Skane University Hospital

  collaborator OTHER

• Karolinska University Hospital

  collaborator OTHER

• Great Ormond Street Hospital for Children NHS Foundation Trust

  collaborator OTHER

• The Royal London Hospital

  collaborator UNKNOWN

• Nuffield Orthopaedic Centre NHS Trust

  collaborator OTHER

• Children's Hospital Medical Center, Cincinnati

  collaborator OTHER

• Boston Children's Hospital

  collaborator OTHER

• Columbia University

  collaborator OTHER

• Shriners Hospitals for Children, Sacramento

  collaborator UNKNOWN

• Gillette Children's Specialty Healthcare

  collaborator OTHER

• Alfred I. duPont Hospital for Children

  collaborator OTHER

• IWK Health Centre

  collaborator OTHER

• Alder Hey Children's NHS Foundation Trust

  collaborator OTHER

• Children's Hospital Colorado

  collaborator OTHER

• Hospital for Special Surgery, New York

  collaborator OTHER

• Shriners Hospitals for Children, Honolulu

  collaborator UNKNOWN

• Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust

  collaborator OTHER_GOV

• Morgan Stanley Children's Hospital

  collaborator OTHER

• Children's Health Queensland Hospital and Health Service

  collaborator UNKNOWN

• University of Nebraska

  collaborator OTHER

• The Hospital for Sick Children

  lead OTHER

Principal Investigators

• Unni G Narayanan · The Hospital for Sick Children

Eligibility

Min Age

2 Years

Max Age

19 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-10-01

Primary Completion

2026-03-31

Completion

2028-03-31

Countries

• Canada

Study Locations