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Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery

NCT04791943 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-01-30

No results posted yet for this study

Summary

The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption. Patients will receive either melatonin or a placebo for three nights prior to surgery.

Conditions

  • Pain, Postoperative
  • Narcotic Use

Interventions

DRUG

Melatonin 10 MG

3 melatonin 10mg capsules will be given to the treatment arm

DRUG

Lactose pill

3 lactose pills will be provided to the control arm

Sponsors & Collaborators

  • Quest Diagnostics-Nichols Insitute

    collaborator INDUSTRY

  • Eurofins Viracor

    collaborator UNKNOWN

  • Montefiore Medical Center

    lead OTHER

Principal Investigators

  • Jason Baker, DMD · Montefiore Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-11-16
Primary Completion
2025-10-01
Completion
2025-10-20

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04791943 on ClinicalTrials.gov