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Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction

NCT00390312 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 225

Last updated 2008-01-04

No results posted yet for this study

Summary

This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7.5 mg and 15 mg, intravenous morphine (IV) 7.5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

Conditions

  • Post-Operative Pain
  • Third Molar Extraction

Interventions

DRUG

Intranasal Placebo

Intranasal placebo

DRUG

Intranasal Morphine 15 mg

Intranasal Morphine 15 mg

DRUG

Immediate Release Oral Morphine 60 mg

Immediate Release Oral Morphine 60 mg

DRUG

Intravenous morphine

Intravenous morphine 7.5 mg

DRUG

Intranasal morphine 7.5 mg

Intranasal morphine 7.5 mg

DRUG

Oral placebo

Oral placebo

DRUG

Intravenous placebo

Intravenous placebo

Sponsors & Collaborators

  • Javelin Pharmaceuticals

    lead INDUSTRY

Principal Investigators

  • Kyle Christensen, DDS · Jean Brown Associates, Inc.

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2001-09-30
Primary Completion
2001-11-30
Completion
2001-11-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00390312 on ClinicalTrials.gov