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Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery

NCT04730297 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2021-01-29

No results posted yet for this study

Summary

To compare analgesic effects of preoperative administration of paracetamol 500 milligram plus codeine 30 milligram in single-tablet and effervescent formulation to ibuprofen 400 milligram, and placebo in the management of moderate to severe postoperative pain after mandibular third molar surgery.

Conditions

  • To Control Pain After Third Molar Surgery

Interventions

DRUG

paracetamol 500 mg plus codeine 30 mg preoperative administration

each patient 30 minutes before surgery received paracetamol 500 mg plus codeine 30 mg

DRUG

ibuprofen 400 mg preoperative administration

each patient 30 minutes before surgery received ibuprofen 400 mg

DRUG

Placebo oral tablet preoperative administration

each patient 30 minutes before surgery received placebo

Sponsors & Collaborators

  • University of Roma La Sapienza

    lead OTHER

Principal Investigators

  • Maria Paola Cristalli, DDS, PhD · University of Roma La Sapienza

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
15 Years
Max Age
29 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2020-09-04
Completion
2020-10-14

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04730297 on ClinicalTrials.gov