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Individualized PEEP in Thoracic Surgery

NCT04740151 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2022-09-28

No results posted yet for this study

Summary

Intraoperative protective ventilation with low tidal volumes (TV), positive end-expiratory pressure (PEEP) and possibly lung recruitment maneuvers (RMs) reduces postoperative pulmonary complications. In thoracic surgery, in one-lung ventilation (OLV), the evidence is lacking. However, in this context protective ventilation with PEEP titration is related to better intraoperative oxygenation and respiratory mechanics. It is not clear whether this strategy is associated also with better postoperative oxygenation and less postoperative pulmonary complications.

Conditions

  • Thoracic Surgery
  • One-lung Ventilation
  • Respiratory Mechanics
  • Artificial Respiration

Interventions

PROCEDURE

Best PEEP

In OLV, the investigator will perform a PEEP decremental titration trial, decreasing PEEP from 16 to 4 cmH2O (steps of 2-cmH2O, lasting 1 minute). At the end of every step driving pressure (Pplat-PEEP) will be calculated, and the PEEP corresponding to the lowest driving pressure + 2cmH2O will be set.

PROCEDURE

Standard PEEP

In OLV, a PEEP of 5 cm H2O will be set.

Sponsors & Collaborators

  • University of Trieste

    lead OTHER

Principal Investigators

  • Lucia Comuzzi · Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI)

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-04
Primary Completion
2021-12-04
Completion
2021-12-05

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04740151 on ClinicalTrials.gov