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Very Low Tidal Volume vs Conventional Ventilatory Strategy for One-lung Ventilation in Thoracic Anesthesia

NCT01504893 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 984

Last updated 2022-12-02

No results posted yet for this study

Summary

The purpose of this study is to determine if a protective ventilatory strategy during one-lung ventilation (OLV) based on low tidal volume, PEEP and alveolar recruitment maneuver can reduce Acute Respiratory Distress Syndrome (ARDS) and Postoperative pulmonary complications (PPCs) after major pulmonary resection.

Primary endpoint: Evaluation of postoperative ARDS incidence

Secondary endpoint: Evaluation od PPC incidence and postoperative outcomes (other complications, unplanned Intensive Care Admission, hospital and ICU length of stay, in-hospital mortality)

Conditions

  • Acute Respiratory Distress Syndrome

Interventions

PROCEDURE

Protective one lung ventilation

Low tidal volume, PEEP and alveolar recruitment maneuver

Sponsors & Collaborators

  • Azienda Ospedaliera S. Maria della Misericordia

    lead OTHER

Principal Investigators

  • Giorgio Della Rocca, MD, Prof · Azienda Ospedaliero-Universitaria S. Maria della Misericordia - Udine. Italy

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-09-30
Primary Completion
2016-08-31
Completion
2017-09-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01504893 on ClinicalTrials.gov