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Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome

NCT04717427 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2024-09-19

No results posted yet for this study

Summary

Individuals with Sturge-Weber Syndrome (SWS) sometimes have brain involvement which can result in seizures, stroke-like episodes and neurologic deficits. The purpose of this study is to integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients.

The research aims are:

1. To integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients.
2. Identify plasma and imaging biomarkers sensitive to exacerbation of clinical symptoms including seizures, headaches, or stroke-like episodes.
3. For enrolled patients who present with severe neurological symptoms screen blood samples for inflammatory changes.

The target enrollment for this study is about 250 individuals diagnosed with Sturge-Weber Syndrome. The goal of this study is to understand more about Sturge-Weber Syndrome, the possible treatments for this disease, and identify targets for clinical trials. Those participating in the database will be asked to consent to blood draws.

Conditions

  • Sturge-Weber Syndrome

Sponsors & Collaborators

  • University of California, San Francisco

    collaborator OTHER

  • Wayne State University

    collaborator OTHER

  • Duke University

    collaborator OTHER

  • Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

    collaborator OTHER

  • Children's Hospital Medical Center, Cincinnati

    collaborator OTHER

  • Boston Children's Hospital

    collaborator OTHER

  • Nationwide Children's Hospital

    collaborator OTHER

  • Sturge-Weber Foundation

    collaborator OTHER

  • University of Illinois at Chicago

    lead OTHER

Principal Investigators

  • Jeffrey Loeb, MD, PhD · University of Illinois at Chicago

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-08
Primary Completion
2025-06-30
Completion
2025-06-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04717427 on ClinicalTrials.gov