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Neuropsychiatry and Cognition in SCA3/MJD

NCT04714307 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 144

Last updated 2021-01-19

No results posted yet for this study

Summary

This research investigates how cognitive-affective aspects evolve during the course of SCA3/MJD. Due to COVID-19 pandemics, this study protocol was adapted for online-only consultations. Evaluations happening after March 2020 have been done by videocall with patients, and no neurological evaluation was thus performed on these patients. A scale on Activities of Daily Living was added to the online protocol to replace SARA, SCAFI and CCFS scales.

Conditions

  • Spinocerebellar Ataxia Type 3
  • Machado-Joseph Disease
  • SCA3
  • MJD

Interventions

DIAGNOSTIC_TEST

SCA3/MJD molecular diagnosis

Double-blind molecular diagnosis for determination of the presence of the mutation.

DIAGNOSTIC_TEST

Cognitive Testing

Cross-sectional Cognitive evaluation with * CCAS Scale * Trail-Making Test parts A and B * Stroop Color-Word Test

DIAGNOSTIC_TEST

Psychiatric Evaluation

Cross-sectional Psychiatric evaluation with Hamilton-Anxiety and Hamilton-Depression rating scales.

DIAGNOSTIC_TEST

Clinical Neurological Evaluation

Cross-sectional neurological evaluation with standardized clinical scales - SARA, SCAFI and CCFS.

DIAGNOSTIC_TEST

Emotional Attribution Evaluation

Cross-sectional emotional attribution evaluation by means of the Reading the Mind in the Eyes Test (RMET).

DIAGNOSTIC_TEST

Activities of Daily Living

Cross-sectional evaluation of Activities of Daily Living (ADLs) by means of Friedreich Ataxia Rating Scale Part II.

Sponsors & Collaborators

  • Hospital de Clinicas de Porto Alegre

    lead OTHER

Principal Investigators

  • Laura B. Jardim, MD, PhD · Hospital de Clinicas de Porto Alegre and Universidade Federal do Rio Grande do Sul

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-12-13
Primary Completion
2021-02-01
Completion
2023-08-01

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04714307 on ClinicalTrials.gov