"Manual Dexterity and Oculomotor Control in Schizophrenia"

Summary

The investigators recently showed that visuomotor integration was significantly altered in schizophrenic patients during: (i) a grip force task (Teremetz et al., 2014), and (ii) a saccadic paradigm (oculomotor task)(Amado et al., 2008). Given this findings, the investigators propose a combined study of oculomotor and grip force control to better characterize the sensorimotor integration deficit. This approach may allow for identification of behavioural biomarkers of vulnerability to develop schizophrenia.

Conditions

• Schizophrenia

Interventions

DEVICE

Manual dexterity

Control of manual dexterity will be assessed by a force sensor (Power Grip Manipulandum, PGM)

DEVICE

Oculomotor movements

Oculomotor movements during behavioral task will be recorded using a video-oculography device

DEVICE

TMS coupled to EMG recording

The involvement of cortical inhibition in this volitional inhibition task will be studied by neuronavigation guided TMS coupled to EMG recording

OTHER

Psychopathological evaluations

OTHER

Neuropsychological evaluations

Sponsors & Collaborators

• University of Paris 5 - Rene Descartes

  collaborator OTHER

• Institut National de la Santé Et de la Recherche Médicale, France

  collaborator OTHER_GOV

• Centre Hospitalier St Anne

  lead OTHER

Principal Investigators

• Isabelle Amado, Dr · CHSA

• Pavel Lindberg, PhD · Institut National de la Santé Et de la Recherche Médicale, France

Study Design

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-07-26

Primary Completion

2018-09-30

Completion

2019-01-31

Countries

• France

Study Locations