Neoadjuvant Atezolizumab in Surgically Resectable Advanced Cutaneous Squamous Cell Carcinoma
NCT04710498 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2025-02-03
Summary
The purpose of this research is to evaluate whether the administration of atezolizumab before surgical resection of the tumor is feasible and to evaluate the treatment response, safety, and tolerability of atezolizumab.
Conditions
Interventions
- DRUG
-
Atezolizumab administered intravenous (IV) infusion at a fixed dose of 1200 mg
Sponsors & Collaborators
-
Genentech, Inc.
collaborator INDUSTRY - lead OTHER
Principal Investigators
-
Vasu Divi, MD · Stanford Universiy
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-06-22
- Primary Completion
- 2024-02-07
- Completion
- 2024-02-15
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Vaccine Therapy in Treating Patients With Primary Stage II Melanoma
NCT00005052 ·Status: UNKNOWN ·Phase: PHASE3
-
Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed With Surgery
NCT00086866 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of Atezolizumab in Unresectable or Advaced Malignant Pleural Mesothelioma
NCT03786419 ·Status: WITHDRAWN ·Phase: PHASE2
-
Immunotherapy of Stage III/IV Melanoma Patients
NCT00112242 ·Status: COMPLETED ·Phase: PHASE1
-
Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum
NCT02054104 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Tumor Cell Vaccines With ISCOMATRIX Adjuvant and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers and Malignant Pleural Mesotheliomas
NCT01258868 ·Status: TERMINATED ·Phase: PHASE1
-
Avelumab With or Without Cetuximab in Treating Patients With Advanced Skin Squamous Cell Cancer
NCT03944941 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study to Compare the Safety and Efficacy of CMB305 With Atezolizumab to Atezolizumab Alone in Participants With Sarcoma (IMDZ-C232/V943A-002)
NCT02609984 ·Status: TERMINATED ·Phase: PHASE2
-
Using a Targeted Cancer Vaccine (Galinpepimut-S) With Immunotherapy (Nivolumab) in Mesothelioma
NCT04040231 ·Status: COMPLETED ·Phase: PHASE1
-
Vaccine Therapy and Resiquimod in Treating Patients With Stage II, Stage III, or Stage IV Melanoma That Has Been Completely Removed by Surgery
NCT00470379 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Melanoma Vaccine in Treating Patients With Stage III Melanoma After Surgery to Remove Lymph Nodes
NCT01082198 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Vaccine Therapy in Treating Patients Who Have Stage II, Stage III, or Stage IV Melanoma
NCT00010309 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Interleukin-7 and Vaccine Therapy in Treating Patients With Metastatic Melanoma
NCT00091338 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Atezolizumab (an Engineered Anti-Programmed Death-Ligand 1 [PDL1] Antibody) to Evaluate Safety, Tolerability and Pharmacokinetics in Participants With Locally Advanced or Metastatic Solid Tumors
NCT01375842 ·Status: COMPLETED ·Phase: PHASE1
-
Vaccine Therapy in Treating Patients With Stage IV Cutaneous Melanoma
NCT00074230 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Vaccine Therapy Using Melanoma Peptides for Cytotoxic T Cells and Helper T Cells in Treating Patients With Metastatic Melanoma
NCT00071981 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of GC101 TIL in Advanced Melanoma
NCT06703398 ·Status: RECRUITING ·Phase: PHASE2
-
An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)
NCT03897881 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Monoclonal Antibody and Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Has Been Removed During Surgery
NCT00025181 ·Status: COMPLETED ·Phase: PHASE1
-
Vaccine Therapy in Treating Patients With Stage IIC-IV Melanoma
NCT00085189 ·Status: COMPLETED ·Phase: PHASE2
-
Vaccine Therapy in Treating Patients With Stage IV Melanoma
NCT00042783 ·Status: COMPLETED ·Phase: PHASE2
-
Sargramostim, Vaccine Therapy, or Sargramostim and Vaccine Therapy in Preventing Disease Recurrence in Patients With Melanoma That Has Been Removed By Surgery
NCT01989572 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Atezolizumab Administered in Combination With Bevacizumab and/or With Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
NCT01633970 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1 Study to Evaluate MEDI6383 Alone and in Combination With MEDI4736 in Adult Subjects With Select Advanced Solid Tumors
NCT02221960 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Atezolizumab as Adjuvant Therapy in Participants With Renal Cell Carcinoma (RCC) at High Risk of Developing Metastasis Following Nephrectomy
NCT03024996 ·Status: TERMINATED ·Phase: PHASE3