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Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculography

NCT04705610 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 76

Last updated 2021-01-22

No results posted yet for this study

Summary

This study aims to:

* analyze prospectively the prevalence of subclinical oculomotor disorders (OMDs) in different phenotypes of Multiple Sclerosis (MS) and to study correlations with brain MRI T2 data.
* highlight link between modification of visual exploration strategies to decode emotions, and social behavioral disorders, in patients with demyelinating disease, from early to clinically definite stages.

Conditions

  • Multiple Sclerosis (MS)
  • Multiple Sclerosis (MS) Relapsing Remitting
  • Multiple Sclerosis (MS) Primary Progressive
  • Multiple Sclerosis (MS) Secondary Progressive
  • Radiologically Isolated Syndrome
  • Clinically Isolated Syndrome
  • Healthy

Interventions

OTHER

Video-oculography / Social cognition tasks / Neuropsychological evaluations

* Recording of eye movements with a video-oculography device during oculomotor paradigms (Fixations, horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit, anti-saccades) * Recording of eye gaze with a video-oculography device during emotions recognition tasks (Reading the Mind in the Eyes test (Baron-Cohen 2001); Ekman Faces task (1976)) * Neurological evaluation * Neuropsychological evaluations * Social cognitions tasks * Behaviour assessment

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Nice

    collaborator OTHER

  • Centre Hospitalier Princesse Grace

    collaborator OTHER

  • Association de Recherche Bibliographique pour les Neurosciences

    lead OTHER

Principal Investigators

  • Christine LEBRUN-FRENAY, PUPH · Centre de Ressources et de Compétences SEP, UMRC Pasteur 2, Université Nice Côte d'Azur, Nice-France

  • Alain PESCE, PUPH · Centre Mémoire, Centre de Gérontologie Clinique RAINIER III, Princess Grace Hospital (Monaco)

  • Benoit KULLMANN, MD-PHD · AREBISN (Association de Recherche Bibliographique pour les Neurosciences), Nice (France)

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-05-23
Primary Completion
2019-06-26
Completion
2019-06-26

Countries

  • Monaco

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04705610 on ClinicalTrials.gov