EMISEP : Early Spinal Cord Lesions and Late Disability in Relapsing Remitting Multiple Sclerosis Patients

Summary

The purpose of this study is to evaluate the prognostic value of early focal lesions and early diffuse lesions on ambulatory disability progression within 5 years after clinical onset.

Conditions

• Multiple Sclerosis

Interventions

DEVICE

spinal cord MRI follow-up

Evaluation : focal lesions (number, volume, localisation), atrophy, parameters from Diffusion Tensor Imaging and parameters from Magnetization Transfer Ratio

OTHER

clinical follow-up

Relapses, treatments, global disability,walking performance, upper limbs motor performance, sphincter disturbances and walking difficulty

OTHER

brain MRI follow-up

Sponsors & Collaborators

• Rennes University Hospital

  lead OTHER

Principal Investigators

• Gilles GE Edan · CHU Rennes

• Bruno BB Brochet · University Hospital, Bordeaux

• Thibault TM Moreau · CHU Dijon

• Sandra SV Vukusic · Hospices civils Lyon

• Jean JP Pelletier · AP-HM

• Marc MD Debouverie · CHU NANCY

• Bruno BS Stankoff · Pitié Salpêtrière

• Ayman AT Tourbah · CHU REIMS

• Jérôme JD De Seze · CHU Strasbourg

• David DB Brassat · University Hospital, Toulouse

• Pierre PL Labauge · University Hospital, Montpellier

• Thibaut TM Moreau · University Hospital, Clermont-Ferrand

Study Design

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-01-31

Primary Completion

2022-04-30

Completion

2022-07-31

Countries

• France

Study Locations