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Community Dynamics of Malaria Transmission in Humans and Mosquitoes in Fleh-la and Marshansue, Salala District, Bong County, Liberia

NCT04704674 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 396

Last updated 2026-01-16

No results posted yet for this study

Summary

Background:

Malaria is a disease that affects many people in Liberia. It is caused by germs (parasites) that are spread by mosquito bites. Researchers want to gather data that may help them understand the best way to use a malaria vaccine in Liberia, which will be important in getting rid of the disease.

Objective:

To find out how often people of all ages who live in Fleh-la and Marshansue, Liberia, get malaria.

Eligibility:

Healthy people ages 6 months and older who live in Fleh-la and Marshansue in a household with adults and children.

Design:

Participants will be screened with a physical exam and questions about their health.

Participants will have monthly study visits. They will be asked about any symptoms of malaria and their use of bednets. Their vital signs, such as blood pressure and temperature, will be checked. Blood will be taken from the participant s arm or finger with a needle. If they have a fever, they will get a malaria test. If positive, they will get drugs to treat malaria.

Once a month, participants houses will be examined for mosquitoes. The team will remove all mosquitoes they collect. As part of this collection, participants houses will be sprayed with a chemical to kill mosquitoes and other insects. Participants will not be allowed in their house while the team is inside. The spray will not harm the participants.

Once a year, at the monthly visit, an additional blood sample will be taken.

Some of the participants blood samples will be used for genetic testing.

Participation will last for up to 3 years.

Conditions

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Jennifer C Hume · National Institute of Allergy and Infectious Diseases (NIAID)

Eligibility

Min Age
6 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-30
Primary Completion
2023-04-28
Completion
2026-02-28

Countries

  • Liberia

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04704674 on ClinicalTrials.gov