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Population Pharmacokinetics of Ropivacaine

NCT04702282 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2021-01-08

No results posted yet for this study

Summary

The aim of this study was to investigate the pharmacokinetics of free and total ropivacaine after unilateral and bilateral TKA. A population model was successfully built and peak free ropivacaine concentration stayed below previously proposed toxic thresholds in patients undergoing unilateral as well as bilateral TKA receiving LIA with high dose ropivacaine.

Conditions

Interventions

DIAGNOSTIC_TEST

ropivacain concentration measurements

Free and total plasma concentrations of ropivacaine were measured within 24 hours using liquid chromatography - mass spectrometry. A population pharmacokinetic model was built using non-linear mixed effect models

Sponsors & Collaborators

  • Hvidovre University Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-01
Primary Completion
2018-05-01
Completion
2019-09-30

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04702282 on ClinicalTrials.gov