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A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty

NCT02543801 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 239

Last updated 2019-10-18

Study results available
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Summary

This study evaluates two routinely used drug combinations for periarticular injection following total hip and knee arthroplasty for pain control. One group will receive liposomal bupivacaine, bupivacaine, clonidine, epinephrine and ketorolac. The other group will receive ropivacaine, clonidine, epinephrine and ketorolac.

Conditions

  • Total Hip and Knee Arthroplasty

Interventions

DRUG

Liposomal Bupivacaine

Periarticular injection

DRUG

Ropivacaine

Periarticular injection

DRUG

Bupivacaine

Included as an element of the Liposomal bupivacaine intervention periarticular injection

DRUG

Clonidine

Included as an element of both interventions as a standard of care periarticular injection

DRUG

Ketorolac

Included as an element of both interventions as a standard of care periarticular injection

DRUG

Epinephrine

Included as an element of both interventions as a standard of care periarticular injection

Sponsors & Collaborators

  • Kootenai Health

    lead OTHER

Principal Investigators

  • Joe Bowen, MD · Kootenai Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-25
Primary Completion
2018-08-21
Completion
2018-08-21

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02543801 on ClinicalTrials.gov