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Does COVID-19 Infection Increase the Risk of Pulmonary Embolism?

NCT04696913 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 347

Last updated 2026-05-19

No results posted yet for this study

Summary

The World Health Organization (WHO) declared the 2019 novel coronavirus (COVID-19) a pandemic on March 11, 2020. As of 19 July 2020, there have been 14.3 million confirmed cases and over 600,000 confirmed deaths. Up to 14% of infected patients develop interstitial pneumonia, which may evolve to acute respiratory distress syndrome.

COVID-19 associated pulmonary arterial microthrombosis and coagulopathy has prompted physicians to implicate pulmonary embolism (PE) as a potential cause for acute respiratory deterioration.

Literature review reveals few studies of varying size, quality and design. Recent meta-analysis reports venous thromboembolism in approximately 20% of COVID-19 patients. There has yet to be a case-controlled study which proves and quantifies the associated between COVID-19 and PE.Confirming and quantifying this association has numerous clinical implications for the treatment of critically unwell patients with COVID-19 infection. For example, clinicians will be more inclined to investigate and treat sudden deteriorations with the knowledge that pulmonary embolism is the commonest cause for said deteriorations.

Conditions

Interventions

DIAGNOSTIC_TEST

Exposure: Positive COVID-19 infection

Exposure: Positive COVID-19 infection as determined by RT-PCR

DIAGNOSTIC_TEST

Exposure: Negative COVID-19 infection

Exposure: Negative COVID-19 infection as determined by RT-PCR

Sponsors & Collaborators

  • University of Aberdeen

    lead OTHER

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2022-03-03
Completion
2022-03-03

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04696913 on ClinicalTrials.gov