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CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

NCT04688190 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2026-05-07

No results posted yet for this study

Summary

This multinational, investigator-initiated registry aims to investigate clinical outcomes of patients undergoing transcatheter mitral valve replacement (TMVR). The registry primarily focuses on patients treated with TMVR in real-world clinical practice.

Patients evaluated for TMVR but not undergoing the procedure are no longer systematically included. Historical data may include such patients who subsequently underwent alternative treatments, including transcatheter edge-to-edge repair, mitral valve surgery, or medical/conservative therapy.

Conditions

  • Mitral Regurgitation
  • Mitral Valve Disease
  • Mitral Annular Calcification

Sponsors & Collaborators

  • Montreal Heart Institute

    collaborator OTHER

  • University Hospital, Bordeaux

    collaborator OTHER

  • Universitätsklinikum Hamburg-Eppendorf

    lead OTHER

Principal Investigators

  • Lenard Conradi, MD · University of Cologne

  • Thomas Modine, MD · University Hospital, Bordeaux

  • Sebastian Ludwig, MD · University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf

  • Juan F Granada, MD · Cardiovascular Research Foundation, New York, USA

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-01
Primary Completion
2030-12-01
Completion
2030-12-31

Countries

  • United States
  • Australia
  • Austria
  • Canada
  • Denmark
  • France
  • Germany
  • Greece
  • Italy
  • Norway
  • Poland
  • Switzerland
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04688190 on ClinicalTrials.gov