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Clinical Investigation Study to Evaluate the Consistency and Reproducibility of Two Consecutive Mosquito Feeding Assays

NCT04666350 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 42

Last updated 2024-04-29

Study results available
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Summary

The proposed trial design has been developed to assess the consistency and reproducibility of two consecutive direct skin feeding assays (DSFA) at 24-hour interval.

Conditions

Interventions

OTHER

Direct Skin Feeding Assay (DSFA)

In the direct feeding assay a cup with 60 unfed, sterile insectary-reared Anopheles gambiae mosquitoes will be allowed to feed on a participant's calf or arm for 15 minutes.

DRUG

Primaquine

Participants will receive one dose of primaquine 26.3 mg tablet on Day 2 after completion of the direct feeding assay.

DRUG

Artemether/Lumefantrine

Participants will receive artemether (80 mg) and lumefantrine (480 mg) combination tablets twice a day for 3 days, starting after completion of the direct feeding assay on Day 2.

Sponsors & Collaborators

  • Walter Reed Army Institute of Research (WRAIR)

    collaborator FED

  • Kenya Medical Research Institute

    collaborator OTHER

  • PATH

    lead OTHER

Principal Investigators

  • Ben Andagalu, MD · Drug Resistance Laboratory, KEMRI

  • Hoseah Akala, MD · Drug Resistance Laboratory, KEMRI

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-03-09
Primary Completion
2021-12-20
Completion
2021-12-20

Countries

  • Kenya

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04666350 on ClinicalTrials.gov