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Obesity-Related Glycine Deficiency: Investigating a Long-standing Metabolic Paradox Using Bedside and Bench Approaches

NCT04660513 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 42

Last updated 2020-12-09

No results posted yet for this study

Summary

Obesity, in addition to causing abnormal glucose and lipid metabolism, is also associated with altered plasma concentrations of multiple amino acids, including increased levels of branched-chain amino acids and decreased levels of glycine. The mechanisms and consequences of obesity- related glycine deficiency are unknown.

The overall aim of this project is to comprehensively study glycine metabolic pathways in morbid obesity using stable-isotope tracer techniques in human subjects and validating kinetic findings using a cell model of oxidative stress.

This will be a single-centre, observational study. 21 individuals with morbid obesity scheduled for bariatric surgery and 21 non-obese controls will be recruit. They will undergo different study visits and procedures and the human biological materials collected will be analysed for as per aims of the studies. We believe that the glycine metabolic pathways, possibly through the optimization of gluthathione (GSH) synthesis, may provide targets to develop novel therapeutic agents.

Conditions

Interventions

PROCEDURE

Bariatric surgery

Subjects with morbid obesity underwent bariatric surgery

Sponsors & Collaborators

  • Duke-NUS Graduate Medical School

    collaborator OTHER

  • Baylor College of Medicine

    collaborator OTHER

  • National University Health System, Singapore

    collaborator OTHER

  • Singapore General Hospital

    lead OTHER

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-08
Primary Completion
2020-11-04
Completion
2020-11-04

Countries

  • Singapore

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04660513 on ClinicalTrials.gov