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Advanced Techniques for Single-fraction Palliative Radiotherapy Versus ASPIRE-single

NCT04658537 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-02-05

No results posted yet for this study

Summary

One third of patients treated in the radiation oncology departments are treated with palliative intent. These patients can be unwell due to their advanced disease and suffering from pain and other symptoms related to metastases. Radiation therapy (RT) has an important role in the symptomatic relief and improvement in the quality of life (QoL) for these patients.The aim of the study is to determine if escalated single fraction palliative radiotherapy using intensity-modulated techniques results in a prolonged duration of benefit for patients otherwise suitable for standard single fraction radiotherapy.

Conditions

  • Palliative Radiotherapy
  • Radiotherapy, Intensity-Modulated

Interventions

RADIATION

Radiation Therapy

Cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumours

Sponsors & Collaborators

  • Royal North Shore Hospital

    lead OTHER

Principal Investigators

  • Thomas Eade · Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-29
Primary Completion
2024-10-04
Completion
2026-12-31

Countries

  • Australia

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04658537 on ClinicalTrials.gov