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Myotonic Dystrophy - Vascular and Cognition

NCT04656210 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 85

Last updated 2026-05-22

No results posted yet for this study

Summary

The cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology.

Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy).

Conditions

  • Myotonic Dystrophy 1
  • Diabetes
  • Carbohydrate Intolerance

Interventions

RADIATION

MRI

Non conventional MRI (35 minutes)

OTHER

neuropsychological tests

Standardized and quantified neuropsychological assessment

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Céline TARD, MD · University Hospital, Lille

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-14
Primary Completion
2024-10-13
Completion
2029-01-31

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04656210 on ClinicalTrials.gov