Insulin Resistance in Multiple System Atrophy

Summary

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder. The pathologic hallmark is the accumulation of aggregated alpha-synuclein in oligodendrocytes forming glial cytoplasmic inclusions. Some symptomatic treatments are available while disease-modification remains an unmet treatment need. Post-mortem findings suggest insulin resistance, i.e. reduced insulin signaling, in the brains of MSA patients. The aim of this study is to complete the target validation of insulin resistance for future treatment trials.

Conditions

• Multiple System Atrophy

Interventions

BIOLOGICAL

Homeostasis Model Assessment of insulin resistance (HOMA)

Fasting blood sample for : glucose, insulinemia, hemoglobin and lipid test to determine the Homeostasis Model Assessment of insulin resistance (HOMA) index

BEHAVIORAL

MOntreal Cognitive Assessment (MoCA)

Cognitive evaluation with MOntreal Cognitive Assessment (MoCA)

BEHAVIORAL

Clinical characteristics of AMS patients

Severity and progression of motor disorders assessed by the UMSARS scale, severity of dysautonomia assessed by the COMPASS31 scale ; quality of life questionnaire (AMS-Qol) for the level of difficulty experienced by the patient (on activities such as : move; walk; maintain balance; talk; feed)

PROCEDURE

Brain Magnetic Resonance Imaging (MRI)

Brain Magnetic Resonance Imaging (MRI) : putamen imaging, bridge and cerebellum; white substance hypersignals volume

BIOLOGICAL

Blood sampling

Optional blood sampling for the constitution of a biological collection

Sponsors & Collaborators

• University of Bordeaux

  collaborator OTHER

• Labex Brain

  collaborator OTHER

• Centre National de la Recherche Scientifique, France

  collaborator OTHER

• University Hospital, Bordeaux

  lead OTHER

Study Design

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

30 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-10-28

Primary Completion

2026-10-28

Completion

2027-10-28

Countries

• France

Study Locations