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A Prospective Study of The Complement Depletion in Patients With Severe Abdominal Sepsis

NCT01568853 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2012-04-06

No results posted yet for this study

Summary

The role of complement system in bridging innate and adaptive immunity has been confirmed in various invasive pathogens. The aim of this study is to investigate the alteration of complement C3 in patients with severe abdominal sepsis and evaluate the role of complement C3 depletion in prognosis of such patients. The relationship between complement C3 depletion and adaptive immunity is studied meanwhile.

Conditions

  • Severe Sepsis
  • Pancreatitis
  • Abdominal Abscess
  • Appendicitis
  • Digestive System Fistula

Interventions

DRUG

Norepinephrine

Intravenously, 10 ug/min, 24 hours

PROCEDURE

Open abdomen

IAH \>=20 mmHg, and ACS emerged, such as low urine and decreased FiO2 quickly.

OTHER

enteral nutrition

500-1500 kcal/day; Nasogastric tube feeding;

OTHER

parenteral nutrition

3000 mL parenteral nutrition fluid, intravenously.

Sponsors & Collaborators

  • Jinling Hospital, China

    lead OTHER

Principal Investigators

  • Jianan Ren, M.D. · Department of Surgery, Jinling Hospital, China

Study Design

Allocation
NA
Purpose
SCREENING
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-11-30
Primary Completion
2012-03-31
Completion
2012-03-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01568853 on ClinicalTrials.gov