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Lung Cancer Risk and Early Detection in Firefighters

NCT04614129 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 734

Last updated 2025-11-24

No results posted yet for this study

Summary

This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.

Conditions

Interventions

DIAGNOSTIC_TEST

Low Dose CT

All participants will have a low dose chest CT either within one year of enrollment or after enrollment

Sponsors & Collaborators

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Erica T Warner, ScD · Massachusetts General Hospital

  • Lecia V Sequist, MD · Massachusetts General Hospital

Study Design

Allocation
NA
Purpose
SCREENING
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-02
Primary Completion
2025-11-01
Completion
2025-11-01
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04614129 on ClinicalTrials.gov