Improving Detection of Early Lung Cancer in a Diverse Population (IDEAL) Study

Summary

The goal of this trial is to (a) identify people at high risk of lung cancer who would benefit from LDCT screening but are currently ineligible based on current lung cancer screening criteria (b) provide the framework to manage patients with Incidental Pulmonary Nodules (IPNs) with appropriate follow-up based on accurate interpretation of the Chest CT scan that is already available and (c) develop a simple, point-of-care, minimally invasive test, focusing on the breath and circulating blood proteins, to detect lung cancer, and develop a method to differentiate between cancerous and non-cancerous nodules using a single. Participants will be asked to answer a questionnaire regarding their age, race/ethnicity, smoking history, and residential history if they have ever been told they have chronic obstructive pulmonary disease (COPD), high blood pressure, education level, medications and height and weight. Participants will then be asked to give a breath sample via the breath collection device. All this information will be collected before the breath collection. After that, participants will give 1-2 tablespoons of blood. CT scans with IPN(s) will be reviewed and run through a computer detection software to identify nodules, followed up as per current clinical guidelines.

Conditions

• Lung Cancer
• Pulmonary Nodule

Interventions

DIAGNOSTIC_TEST

Chest CT Scan

Chest CT Scan

Sponsors & Collaborators

• Laval University

  collaborator OTHER

• Lunenfeld Tanenbaum Research Institute

  collaborator OTHER

• Canadian Cancer Society (CCS)

  collaborator OTHER

• University Health Network, Toronto

  collaborator OTHER

• British Columbia Cancer Agency

  lead OTHER

Principal Investigators

• Renelle L Myers, MD · VCH, UBC

• Rayjean Hung, PhD · Sinai Health

Study Design

Allocation

NA

Purpose

SCREENING

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

50 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-08-04

Primary Completion

2028-12-31

Completion

2028-12-31

Countries

• Canada

Study Locations