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Intra-articular Allocetra in Osteoarthritis of the 1st Carpo-metacarpal Joint

NCT06459063 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2026-04-13

No results posted yet for this study

Summary

This study is a single center trial to assess the safety and efficacy of intra-articular administration of Allocetra to patients with 1st CMC thumb joint osteoarthritis (OA).

Conditions

  • Osteoarthritis Thumb

Interventions

DRUG

Allocetra - Safety run-in phase

Intra-articular injection of Allocetra performed once on Day 1 of the study at different doses.

OTHER

Placebo

Intra-articular injection of placebo solution containing all excipients except for the Allocetra cells.

DRUG

Allocetra - Randomization phase

Intra-articular injection of selected dose of Allocetra based on the safety run-in, performed on Day 1 of the study.

Sponsors & Collaborators

  • Kaplan Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-10
Primary Completion
2026-09-30
Completion
2027-01-31

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06459063 on ClinicalTrials.gov