Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis

Summary

Approximately 40,000 Swedes suffer from sepsiseach year, about 20% die. Biomarkers that are sensitive to current or previous bacteremia are needed in the treatment of sepsis. Bacteremia from periodontal treatment is predictive and occurs in 13-75%. Cardiovascular disease (CVD) is the number one cause of death in industrialized countries and the impact of bacteria and their products need to be elucidated.

The study's hypothesis is to utilize bacteremia from periodontal treatment to evaluate biological markers for current or previous bacteremia.

A. What are the long term clinical, and 'omics related CVD-phenotypical effects from treating periodontal disease compared to an untreated group? B. Can biomarkers be used for detecting a bacteremia or previous bacteremia? C. Are the effects from bacteremia on cardiovascular biomarkers related to the individual's antimicrobial peptide profile? D. Does the presence of bacterial proteases, such as gingipain, relate to having a bacteremia from periodontal treatment and the systemic response from a bacteremia?

Significance: The project has the potential to shorten the time to treat sepsis, which in turn shortens hospital stay and higher survival. The possible definition of protective AMP-profile could translate to future pharmacologic intervention and improve the treatment of sepsis as well as prophylactic treatment at dental treatments. An elucidation of the impact of bacteria and their products on CVD could lead to personalized medicine targeting anti-inflammation and anti-oxidative stress in subjects with periodontitis.

As of March 2024 78 subjects have been included and we anticipate to keep the time-line that we set up.

Conditions

• Bacteremia
• Periodontal Diseases
• Sepsis
• Heart Diseases

Interventions

PROCEDURE

Non-surgical periodontal treatment

Non-surgical periodontal treatment that is accepted to cause bacteremia in about 40% of the cases.

Sponsors & Collaborators

• Skane University Hospital

  collaborator OTHER

• Swedish Dental Service Organisation

  collaborator UNKNOWN

• Malmö University

  lead OTHER

Principal Investigators

• Daniel Jonsson, DDS PhD · Malmo University, Lund University

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-02-25

Primary Completion

2027-12-31

Completion

2027-12-31

Countries

• Sweden

Study Locations