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Effects of Acute Systemic Inflammation on Arterial Stiffness and Microcirculation.

NCT01556373 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 8

Last updated 2019-12-27

No results posted yet for this study

Summary

This study aims to assess the effect of acute inflammation on arterial stiffness and microcirculation. Patients with severe sepsis will be compared with age-, sex- and cardiovascular risk factors-matched controls.

The primary outcome is the carotid-femoral pulse wave velocity. The other outcome measures are: systemic hemodynamics (systolic, diastolic, mean and pulse blood pressures, heart rate, cardiac output, left ventricular ejection fraction, systemic vascular resistances), central hemodynamics (aortic systolic, diastolic, mean and pulse pressures, and augmentation index), thenar tissue oxygen saturation, biological makers of inflammation (plasma fibrinogen, C-reactive protein, interleukin-6, matrix metalloproteinases -2, -9, tissue inhibitor of metalloproteinase 1), and plasma catecholamine concentrations (epinephrine, norepinephrine).

Conditions

  • Severe Sepsis

Interventions

OTHER

NA : non interventional study

NA : non interventional study

Sponsors & Collaborators

  • Rennes University Hospital

    lead OTHER

Principal Investigators

  • Bruno LAVIOLLE, MD, PhD · Rennes University Hospital

  • Eric BELLISSANT, MD, PhD · Rennes University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-02-23
Primary Completion
2015-04-16
Completion
2015-04-16

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01556373 on ClinicalTrials.gov