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Genetic Mechanisms and Additional Risk Factors Underlying Hip Dysplasia

NCT04563819 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1779

Last updated 2020-09-24

No results posted yet for this study

Summary

Hip Dysplasia, or Developmental dysplasia of the hip (DDH) is a congenital disorder of the hip joint characterized by a shallow, or dysplastic hip socket, with potential risks of developing progressive joint dislocation, early osteoarthritis from young adulthood and serious functional disability. The Hip Cohort Study is the first longitudinal, population-based hip "phenobank" which includes standardized ultrasound examinations of the newborn hip, radiographs at skeletal maturity (around 19 years), as well as clinical data and DNA samples from the participants. The combination of genetic analyses with the rich radiological and clinical data collected at different life stages during the first two decades of life will enable identification of biological pathways (advanced genetic analyses) that are significantly associated with different radiological indices of hip dysplasia. This will allow for early, targeted treatment of the DDH disease and thus reduce the risk of later osteoarthritis.

Conditions

  • Developmental Dysplasia of the Hip

Interventions

GENETIC

Genom-wide association study (GWAS) and biological pathway analyses

Sponsors & Collaborators

  • University Hospital of North Norway

    collaborator OTHER

  • Helse Forde

    collaborator OTHER

  • Helse-Bergen HF

    lead OTHER

Principal Investigators

  • Karen Rosendahl, MD PhD · University Hospital of North Norway, The Arctic University of Northern Norway

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-03-31
Primary Completion
2009-03-31
Completion
2009-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04563819 on ClinicalTrials.gov