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Effect of Heat Stress on Global LV Function in Anesthetized Humans

NCT04553900 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 28

Last updated 2020-09-21

No results posted yet for this study

Summary

Recent data suggests that increased temperature improves inotropic function during systole and may improve diastolic function in healthy humans at rest, despite a reduction in left ventricular volume at end diastole. The effect of heat stress has not been reported in patients receiving general anesthesia and the impact of general anesthesia on these findings is not known. Trans-esophageal echocardiography will be used to measure parameters important to both systolic and diastolic function at temperature intervals of 1°C in patients undergoing "Heated Intraoperative Peritoneal Chemotherapy" (HIPEC.) That general anesthesia will not alter the cardiovascular effects of increased temperature that has been reported in healthy, un-anesthetized humans is the hypothesis.

Conditions

  • Hyperthermia
  • Cardiac Functional Disturbances During Surgery

Interventions

DIAGNOSTIC_TEST

Transesophageal Echocardiography

Placement of a transesophageal probe and performance of a diagnostic Transesophageal echocardiography examination.

Sponsors & Collaborators

Principal Investigators

  • Edward O O'Brien, MD · University of California, San Diego

Study Design

Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-06-09
Primary Completion
2019-12-06
Completion
2019-12-06

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04553900 on ClinicalTrials.gov