Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19)

Summary

The first version of this preprint article is registered on the 4th of May 2020 under the digital object identifier of:10.31219/osf.io/u56fc.

COVID-19 infections virus spread worldwide and impact many countries with sever economical sequences. The effective antiviral medication or vaccination for the virus is unavailable until the present date and it takes months or years to discover the effective treatment or test the efficacy of the discovered treatment.

Based on these facts, the human immune system against the virus may have an effective role to regulate the infection and reduce the mortality rate among the infected patients. This proposed research article aims to explore the available medication/ natural supplementation to boost the immunity system of the patients against COVID-19 infections and reduce the mortality rate among infected patients. Methods: a proposed clinical trial will be carried out to investigate the effect of the different treatment modalities on the human immune system against COVID-19 infection.

Conditions

• Covid19
• Immunodeficiency

Interventions

DRUG

Omega 3/Nigella Sativa Oil

Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone

DRUG

Omega 3/Nigella Sativa Oil/Indian Costus

Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Indian Costus supplements

DRUG

Omega 3/Nigella Sativa Oil/Quinine pills

Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Quinine supplementation (1g Quinine)

DRUG

Omega 3/Nigella Sativa Oil/Anise seed capsule

Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Anise seed supplementation (450mg anise seed)

DRUG

Omega 3/Nigella Sativa Oil/Deglycyrrhizinated Licorice

Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Deglycyrrhizinated Licorice 800 mg

DRUG

Active Comparator

Standard protocol care of COVID-19 infection

Sponsors & Collaborators

• Maternity and Children Hospital, Makkah

  collaborator OTHER

• University of Arizona

  collaborator OTHER

• Beni-Suef University

  lead OTHER

Principal Investigators

• HASSAN Masmali [consultant of Pediatrics], M.D · Maternity and Children hospital,Mecca, Saudi Arabia

• MOHAMED M ABDELWAHAB GAMALELDIN, Ph.D Candidate · Beni-Suef University, Faculty of Pharmacy

• SHAIMAA M Nashat SAYED ABDELHALIM, Ph.D Candidate · Beni-Suef University, Faculty of Pharmacy

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

SEQUENTIAL

Eligibility

Min Age

25 Years

Max Age

40 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-09-20

Primary Completion

2020-11-04

Completion

2021-12-04

Countries

• Saudi Arabia

Study Locations