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Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study

NCT04537871 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 350

Last updated 2025-09-25

No results posted yet for this study

Summary

This study evaluates how well the heart, lungs, and muscles are working individually, and how these systems are working together in transplant survivors. Information collected in this study may help doctors to understand why hematopoietic stem cell transplant survivors are at higher risk for developing cardiovascular disease.

Conditions

Interventions

PROCEDURE

Bioelectric Impedance Analysis

Undergo bioelectric impedance analysis

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Cardiopulmonary Exercise Testing

Undergo cardiopulmonary exercise test

PROCEDURE

Echocardiography

Undergo echocardiogram

PROCEDURE

Physical Performance Testing

Undergo physical function tests

PROCEDURE

Pulmonary Function Test

Undergo pulmonary function test

OTHER

Questionnaire Administration

Ancillary studies

PROCEDURE

Ultrasound

Undergo musculoskeletal ultrasound

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • City of Hope Medical Center

    lead OTHER

Principal Investigators

  • Saro H Armenian · City of Hope Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-18
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04537871 on ClinicalTrials.gov