The FDA approved Bristol Myers Squibb’s Breyanzi for adults with relapsed or refractory marginal zone lymphoma after at least two prior systemic therapies. In TRANSCEND FL, the CAR T therapy showed a 95.5% overall response rate and 62.1% complete response rate.
Calls are growing to bring CAR-T cell therapy to New Zealand as the current trial is set to end later this year. There is no clear path to public availability.
WHO in January 2024 launched its first list of priority childhood cancer drug formulations, naming six medicines that still lack optimal child-friendly versions. The agency says about 400,000 children and adolescents develop cancer each year and is working to expand access to safe, effective paediatric formulations.
A phase 1 trial shows denileukin diftitox administered before CAR-T therapy has a favorable safety profile and encouraging efficacy in high-risk DLBCL patients, with an 86% overall response rate and 77% one-year progression-free survival. The treatment demonstrated consistent regulatory T-cell depletion, supporting its immunomodulatory mechanism. Larger controlled studies are needed to confirm these preliminary findings.
The FDA has granted fast track designation to QRX003 for Netherton Syndrome and IBI3003 for relapsed or refractory multiple myeloma, while also accepting regulatory applications for other therapies addressing serious conditions with unmet medical needs.
Researchers report advances in cancer treatment through three distinct approaches: repurposing a heart medication to target lymphoma enzymes, blocking stress proteins to enhance immunotherapy, and developing antibodies that restore immune system attacks on tumors.
The FDA accepted a new drug application for tirabrutinib to treat relapsed or refractory primary central nervous system lymphoma, with a decision expected December 18, 2026. The application is supported by phase 2 trial data showing a 67% overall response rate.
The FDA has accepted a new drug application for tirabrutinib, a BTK inhibitor, for relapsed/refractory primary central nervous system lymphoma under the accelerated approval pathway. The regulatory agency set a PDUFA target action date of December 18, 2026.
The FDA has accepted for filing the New Drug Application for tirabrutinib under the accelerated approval pathway for relapsed or refractory primary central nervous system lymphoma, setting a PDUFA action date of December 18, 2026.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07566377 |
Cord Blood Transplantation in Children and Young Adults With Blood Cancer |
RECRUITING | PHASE2 |
| NCT07456371 |
PIC1 Injection Therapy for Relapsed/Refractory B-NHL |
RECRUITING | PHASE1 |
| NCT07292272 |
Halt Aging in Survivors of Blood Cancers |
RECRUITING | PHASE2 |
| NCT07284927 |
Clinical Study of LV009 Injection for the Treatment of Hematologic and Lymphoid Malignancies |
RECRUITING | PHASE1 |
| NCT07283822 |
Amping up With PemJAK |
RECRUITING | PHASE2 |
| NCT07260812 |
KSV01 Injection for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma |
RECRUITING | PHASE1 |
| NCT07259304 |
Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors |
RECRUITING | |
| NCT07254793 |
Prophylactic and Therapeutic DLI-X for Leukemia Relapse After HCT |
NOT_YET_RECRUITING | PHASE1 |
| NCT07249528 |
A Study of Voice as a Way to Monitor for Side Effects in People Receiving CAR T-Cell Therapy |
RECRUITING | NA |
| NCT07195799 |
Linperlisib Combination With Cyclophosphamide, Prednisone, and Thalidomide (CPT) in R/R NHL |
RECRUITING | PHASE2 |
