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Genetic Testing in Young Adults With Cancer Study

NCT04533555 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 749

Last updated 2025-10-16

No results posted yet for this study

Summary

The overarching goal of our research is to define an evidence-based, sustainable approach to identifying and managing genetic risk among young adults with cancer and their relatives. Conventional practice leaves referral and testing decisions to mostly non-expert clinicians implementing complex guidelines at the point of care, leading to substantial under-utilization. The investigators hypothesize that panel-based universal screening coupled with electronic medical record- (EMR-) based algorithms can improve ascertainment of genetic risk by functioning as an automated, radically simplified default practice in place of repeated single decisions requiring clinician cognitive effort and action.

A secondary goal is to explore differences in ascertainment of genetic risk among first-degree relatives of probands.

Conditions

Interventions

GENETIC

Broad gene panel for young adult cancers

Genetic testing will occur using a broad gene panel for young adult cancers

GENETIC

Standard

Those in the standard group who are considered high risk will have genetic testing done using the standard of care panel as selected by their care provider.

Sponsors & Collaborators

Principal Investigators

  • Katherine L Nathanson, MD · University of Pennsylvania

  • Steven Joffe, MD · University of Pennsylvania

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-01
Primary Completion
2025-09-26
Completion
2025-09-26

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04533555 on ClinicalTrials.gov