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Detecting SARS-CoV-2 in Tears

NCT04526769 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 7

Last updated 2022-10-31

No results posted yet for this study

Summary

Purpose:

* To determine the presence of SARS-CoV-2 in tears
* To determine SARS-CoV-2 receptors in tear production system

Conditions

Interventions

DIAGNOSTIC_TEST

Tear Collection

A microcapillary tube will be placed at the corner of the eyelid so tears can be absorbed to the tube without causing any trauma. The tube will be placed in a transfer tube. Standard virus sampling swabs will be used to collect samples from the same patient's nasopharynx. RT-PCR will be run to determine virus yield in each sample. For the second part of the study, IHC staining will be done on the existing ocular tissue pathology slides to detect the expression of ACE2 and other cell surface and intracellular receptors. The investigators will use existing UMN ocular pathology lab and Lion's Eye Bank tissue samples. These are banked tissue samples that were collected and examined previously and then the remaining tissue samples were stored.

Sponsors & Collaborators

Principal Investigators

  • Hossein Nazari, MD · University of Minnesota

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-01
Primary Completion
2021-12-30
Completion
2021-12-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04526769 on ClinicalTrials.gov