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Human Intestinal Amino Acid Absorption and the Role of a Local RAS

NCT04524494 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2020-08-24

No results posted yet for this study

Summary

This study is to find out what role a local intestinal RAS (renin angiotensin system) plays in the context of amino acid absorption in the human intestinal tract and how this RAS and thus the amino acid absorption is influenced by the RAS-active drugs (angiotensin II AT1 receptor blockers (sartans) or ACE inhibitors).

Conditions

  • Renin-Angiotensin Aldosterone System (RAS)

Interventions

OTHER

biopsy of intestinal tissue

4 intestinal tissue biopsies taken from descending Duodenum, 2 intestinal tissue biopsies taken from Ileum, 2 intestinal tissue biopsies taken from ascending colon (additional to routine biopsies taken for gastrointestinal diagnostic)

OTHER

blood draw

40 ml blood draw (in Heparin blood tubes) (additional to routine blood draw taken for gastrointestinal diagnostic)

OTHER

urine collection

Midstream Urine collection

Sponsors & Collaborators

  • University Children's Hospital Basel

    lead OTHER

Principal Investigators

  • Raphael N Vuille-dit-Bille, Dr. med. · Universitäts-Kinderspital beider Basel (UKBB)

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-01-27
Primary Completion
2011-05-31
Completion
2011-05-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04524494 on ClinicalTrials.gov