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Effect of Glucocorticoids on Inflammation and Bone Metabolism in Patients With Glomerular Disease

NCT04987450 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2021-08-03

No results posted yet for this study

Summary

The aim of the study is to assess the influence of high doses of intravenous corticosteroids on plasma inflammation and bone markers in patients with primary glomerular disease. The study would include 40 patients with chronic kidney disease. The main inclusion criterion is clinical and histopathological diagnosis of primary glomerular disease and urine protein excretion \>2.0 g/24h. The exclusion criteria include secondary glomerular disease, acute kidney injury, acute or chronic inflammation, history of non-compliance.

Conditions

  • Glomerular Disease

Interventions

DRUG

Methylprednisolone, prednisone

The patients receive intravenous pulses of methylprednisolone 20-30 mg/kg/day for three consecutive days followed by oral prednisone 0.8-1.0 mg/kg/day.

Sponsors & Collaborators

  • Medical University of Lodz

    lead OTHER

Principal Investigators

  • Michał Nowicki, Prof. MD. · Department of Nephrology, Hypertension and Kidney Transplantation Medical University of Lodz, Poland

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-10-01
Primary Completion
2021-07-30
Completion
2021-07-30

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04987450 on ClinicalTrials.gov