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Plantarflexor PAS - Stroke

NCT04515407 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2024-02-22

No results posted yet for this study

Summary

The current project investigates a method called paired associative stimulation (PAS) which is known to influence nervous system function through a process called neuroplasticity. Here the investigators will target function of the ankle plantarflexor muscles because they are critically important to walking. The investigators will study adults who have walking dysfunction resulting from stroke. The study will test three ways of delivering PAS targeted towards brain-muscle connections serving the ankle plantarflexors. The overall goal is to improve functioning of the plantarflexors. The investigators believe that improving plantarflexor function will increase the likelihood of positive effects from gait retraining programs for people post-stroke. Participants will experience all three PAS methods in separate sessions. The investigators will compare differences in the size of these effects to identify the optimal method for delivery of PAS to the ankle plantarflexors. This study is a preliminary step to help us design a better clinical trial of combined PAS and gait retraining.

Conditions

  • Stroke
  • Hemiparesis
  • Gait Dysfunction

Interventions

OTHER

PAS at Rest

Paired Associative Stimulation will be delivered while the participant is seated and resting.

OTHER

PAS - Active

Paired Associative Stimulation will be delivered while the participant is seated and producing submaximal background activity in the plantarflexor muscles.

OTHER

PAS - Walking

Paired Associative Stimulation will be delivered while the participant is walking, during the late stance phase of the gait cycle.

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Carolynn Patten, PhD · Martinez Outpatient Clinic and Community Living Center, Martinez, CA

Study Design

Allocation
NA
Purpose
OTHER
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-01
Primary Completion
2023-08-31
Completion
2023-09-30

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04515407 on ClinicalTrials.gov