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Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization

NCT07220005 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2025-12-23

No results posted yet for this study

Summary

The goal of this research study is to optimize the parameter of Low-Intensity Focused Ultrasound Stimulation (LIFUS) that is most effective in changing cortical excitability and motor learning skills in patients who suffered a stroke. The researchers hope to answer two questions.

* with increasing power, would LIFUS be more effective?
* with the same power, what LIFUS timing is the best

For Aim 1, the study will compare 8, 4 W/cm\^2 to a zero(sham) stimulation to see if higher power is the better.

For Aim 2, the study will compare 500 vs 1000 vs 2000 Hz "timing" to see which one is better.

Conditions

  • Stroke
  • Arm Weakness as a Consequence of Stroke
  • Upper Extremity Hemiparesis
  • Upper Extremity Impairments
  • Upper Extremity Weakness

Interventions

DEVICE

Low intensity focused ultrasound stimulation

A low-intensity focused ultrasound stimulation

Sponsors & Collaborators

Principal Investigators

  • Wayne Feng, MD MS · Duke University

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-10
Primary Completion
2026-05-01
Completion
2026-06-30
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07220005 on ClinicalTrials.gov