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Orphenadrine Versus Baclofen in Treatment of Muscle Cramps in Cirrhotic Patients

NCT04509336 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 5

Last updated 2022-04-29

No results posted yet for this study

Summary

Muscle cramps are commonly affects patients with cirrhosis. It adversely influences the quality of life of cirrhotic patients. Treatment of muscle cramps still challenging owing to the diversity of the responsible pathophysiological mechanisms.The effectiveness of baclofen and orphenadrine in controlling muscle cramps in cirrhotic patients has been presented in recent randomised controlled clinical trials;however, the comparative efficacy and safety between these two therapeutic options has not been previously investigated.

Conditions

  • Cirrhosis

Interventions

DRUG

Orphenadrine

100 mg twice daily

DRUG

Baclofen

initial dose of 10 mg tablet once daily, dose will be gradually increased according to the patients responses

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Principal Investigators

  • Assem Elfert · Tanta University

  • Sherif Abd-Elsalam · Tanta University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-08-20
Primary Completion
2020-12-01
Completion
2021-09-20

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04509336 on ClinicalTrials.gov