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Brain White Matter Injury in Late Preterm Infants

NCT04508517 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 3000

Last updated 2020-08-11

No results posted yet for this study

Summary

At 34 weeks, the brain weight of preterm infants is only 65% that of term infants, and the cortex volume is 53% that of term infants. Damage at this stage of development will also change the trajectory of specific processes in the development of neurons and glial cells, resulting in neurological dysfunction in survivors.The incidence of cerebral palsy in late preterm infants is three times higher than in term infants, and about 25% lag behind term infants in learning, language and other neurodevelopment. At 34-37 weeks of gestation, oligodendrocytes are still late oligodendrocyte precursors and vascular development of the white matter area is immature, making the brain more prone to white matter injury (WMI).

Conditions

  • White Matter Injury

Sponsors & Collaborators

  • Shengjing Hospital

    lead OTHER

Principal Investigators

  • Jian Mao, doctor · Shengjing Hospital

Eligibility

Min Age
1 Day
Max Age
28 Days
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-01-31
Primary Completion
2022-06-30
Completion
2022-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04508517 on ClinicalTrials.gov