MRI-based Biomarkers for Predicting Punctate White Matter Lesions in Neonates

Summary

As a common white matter (WM) disease in preterm neonates, punctate white matter lesion (PWML) frequently leads to the abnormalities of brain development (e.g. the motor, visual and auditory disorders), even to cerebral palsy (CP) and amblyopia during childhood. However, it is lack of certain methods in identifying the prognosis of PWML. Through using various advanced MRI techniques, neuro-behavioral and visual assessments, a multicenter longitudinal study would be conducted to follow-up the PWML neonates with varying spatial-position and degree lesions. Through tracking the variations in WM microstructures from neonate period to childhood (2 years old and 3 years old), this study aims to explore (1) the potential relations between varying PWMLs and motor and visual disorders (2) the relations between WM MRI-metrics and neurodevelopmental assessment results, and thus determine the early biomarkers to identify CP and amblyopia.

Conditions

• Brain Diseases
• Amblyopia
• Brain Damage, Chronic
• Cerebral Palsy

Sponsors & Collaborators

• Shenzhen Children's Hospital

  collaborator OTHER_GOV

• General Hospital of Ningxia Medical University

  collaborator OTHER

• Xijing Hospital

  collaborator OTHER

• Shengjing Hospital

  collaborator OTHER

• Second Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Zunyi Medical College

  collaborator OTHER

• Shaanxi Provincial People's Hospital

  collaborator OTHER

• Baoji Central Hospital

  collaborator OTHER

• Children's Hospital of Fudan University

  collaborator OTHER

• Hainan People's Hospital

  collaborator OTHER

• First Affiliated Hospital Xi'an Jiaotong University

  lead OTHER

Eligibility

Min Age

1 Day

Max Age

28 Days

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-01-31

Primary Completion

2019-06-30

Completion

2019-12-31

Countries

• China

Study Locations