Inflammatory Cytokines Associated With Perinatal Brain Injury

Summary

This observational study assessed whether measurements of certain pro-inflammatory and anti-inflammatory cytokines in the blood (either singly or in combination) at birth and/or up to day of life 21 can predict cerebral palsy at 18-22 months corrected age.

Conditions

• Infant, Newborn
• Infant, Low Birth Weight
• Infant, Small for Gestational Age
• Infant, Premature
• Cerebral Palsy

Sponsors & Collaborators

• Centers for Disease Control and Prevention

  collaborator FED

• National Center for Research Resources (NCRR)

  collaborator NIH

• NICHD Neonatal Research Network

  lead NETWORK

Principal Investigators

• William Oh, MD · Brown University, Women & Infants Hospital of Rhode Island

• Michele C. Walsh, MD MS · Case Western Reserve University, Rainbow Babies & Children's Hospital

• Ronald N. Goldberg, MD · Duke University

• Barbara J. Stoll, MD · Emory University

• James A. Lemons, MD · Indiana University

• Abhik Das, PhD · RTI International

• David K. Stevenson, MD · Stanford University

• Waldemar A. Carlo, MD · University of Alabama at Birmingham

• Neil N. Finer, MD · University of California, San Diego

• Edward F. Donovan, MD · Children's Hospital Medical Center, Cincinnati

• Shahnaz Duara, MD · University of Miami

• Lu-Ann Papile, MD · University of New Mexico

• Sheldon B. Korones, MD · University of Tennessee

• Jon E. Tyson, MD MPH · The University of Texas Health Science Center, Houston

• Abbot R. Laptook, MD · University of Texas

• T. Michael O'Shea, MD MPH · Wake Forest University

• Seetha Shankaran, MD · Wayne State University

• Richard A. Ehrenkranz, MD · Yale University

Eligibility

Max Age

72 Hours

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

1999-07-31

Primary Completion

2002-07-31

Completion

2004-05-31

Countries

• United States

Study Locations